Zopangira zoyera Thymosin Beta 4 TB500/ TB-500 fragment cas 885340-08-9

TB500 ndi molekyulu yopangidwa m'chigawo chogwira ntchito cha thymosin beta 4. TB500 imalimbikitsa kusiyana kwa maselo a endothelial, angiogenesis mu minofu ya dermis, kusuntha kwa maselo, kuika kwa collagen ndi kuchepetsa kutupa.Tanthauzirani angiogenesis (ANG), mapuloteni a 14,124 Da ogwirizana ndi angiogenesis mukukula kwa chotupa.Imatulutsidwa ndi maselo otupa, omwe ndi othandizira kuti apange mitsempha yatsopano yamagazi.
Makhalidwe apangidwe Acharya et al.adatsimikiza mawonekedwe a kristalo a ma antigen a anthu pa 2.4 0 A. Chikhalidwe chonsecho chili ndi makutu atatu owoneka ngati impso monga RNaseA.The RNA lysis ntchito pakati (His-13, His-114 ndi Lys-40) ndi zongopeka receptor kumanga malo, awiri ofunikira participatory biological ntchito zosiyana ndi Rnase A 5. Pakatikati pa molekyulu imakhala ndi P- Zomangamanga zokhala ndi zosokoneza zotsutsana ndi zofanana, kupanga topology yayikulu, yokhala ndi zotsalira za Ser-72 ndi Gly-99 pama vertices.Kapangidwe kake kofoka kakumalizidwa ndi maunyolo awiri owonjezera mbali zonse za maunyolo apakati awa (otsalira 41-47; 111-116).Pali 3 helix H1, yotsalira 3-14, H2, yotsalira 22-33 ndi H3, ndi 49-58 yotsalira.