Malangizo ogwiritsira ntchito desmopressin acetate

Mankhwala osokoneza bongo amawonjezera chiopsezo chosunga madzi ndi hyponatremia.Kasamalidwe ka hyponatremia amasiyanasiyana munthu ndi munthu.Odwala omwe ali ndi hyponatremia yopanda chizindikiro, desmopressin iyenera kusiyidwa ndikuchepetsa kumwa kwamadzimadzi.Odwala ndi symptomatic hyponatremia, m'pofunika kuwonjezera isotonic kapena hypertonic sodium kolorayidi pa kukapanda kuleka.Pakakhala kusungidwa kwamadzi kwambiri (kokomoka ndi kutaya chidziwitso), chithandizo cha furosemide chiyenera kuwonjezeredwa.

Odwala ndi chizolowezi kapena psychogenic ludzu;kusakhazikika kwa angina pectoris;kagayidwe kachakudya dysregulation mtima kulephera;mtundu IIB vascular hemophilia.Chisamaliro chapadera chiyenera kuperekedwa ku chiopsezo cha kusunga madzi.Kumwa madzimadzi kuyenera kuchepetsedwa kukhala pang'ono momwe kungathekere ndipo kulemera kwake kuyenera kuyang'aniridwa pafupipafupi.Ngati pali kuwonjezeka kwapang'onopang'ono kulemera kwa thupi ndipo magazi a sodium achepa pansi pa 130 mmol / L kapena plasma osmolality igwera pansi pa 270 mosm / kg, kumwa kwamadzimadzi kuyenera kuchepetsedwa kwambiri ndikusiya desmopressin.Gwiritsani ntchito mosamala odwala omwe ali aang'ono kapena okalamba;odwala omwe ali ndi zovuta zina zomwe zimafunikira diuretic mankhwala amadzimadzi ndi/kapena kusungunuka kwamadzi;komanso kwa odwala omwe ali pachiwopsezo chowonjezereka cha kuthamanga kwa intracranial.Zinthu coagulation ndi magazi nthawi ayenera kuyeza musanayambe ntchito mankhwalawa;Kuchuluka kwa madzi a m'magazi a VIII: C ndi VWF: AG kumawonjezeka kwambiri pambuyo pa makonzedwe, koma sizinatheke kukhazikitsa kugwirizana pakati pa milingo ya plasma ya zinthuzi ndi nthawi yotaya magazi isanayambe kapena itatha.Chifukwa chake ngati kuli kotheka, zotsatira za desmopressin pa nthawi yotaya magazi mwa wodwala aliyense payekha ziyenera kudziwitsidwa moyesera.

Kutsimikiza kwa nthawi yotaya magazi kuyenera kukhazikitsidwa momwe kungathekere, mwachitsanzo, ndi njira ya Simlate II.Zotsatira pa Mimba ndi Kuyamwitsa Mayeso a uchembele ndi makoswe ndi akalulu omwe amaperekedwa mopitilira zana limodzi pamlingo wamunthu awonetsa kuti desmopressin siyivulaza mwana wosabadwayo.Wofufuza wina wanenapo milandu itatu ya kusokonekera kwa makanda obadwa kwa amayi apakati a uremic amene anagwiritsira ntchito desmopressin panthaŵi yapakati, koma malipoti ena a milandu yoposa 120 asonyeza kuti makanda obadwa kwa amayi amene anagwiritsira ntchito desmopressin panthaŵi ya mimba anali abwinobwino.

Kuonjezera apo, kafukufuku wolembedwa bwino adawonetsa kuti palibe kuwonjezeka kwa chiwopsezo cha kubadwa kwa makanda 29 obadwa kwa amayi apakati omwe amagwiritsa ntchito desmopressin panthawi yonse ya mimba.Kuwunika kwa mkaka wa m'mawere kuchokera kwa amayi oyamwitsa omwe amapatsidwa Mlingo wambiri (300ug intranasal) kunawonetsa kuti kuchuluka kwa desmopressin kuperekedwa kwa khanda kunali kocheperako poyerekeza ndi kuchuluka komwe kumafunikira kukhudza diuresis ndi hemostasis.

Kukonzekera: Mankhwala oletsa kutupa amatha kupititsa patsogolo kuyankha kwa wodwala ku desmopressin osatalikitsa nthawi yake yochitapo kanthu.Zinthu zina zomwe zimadziwika kuti zimatulutsa mahomoni a antidiuretic, monga tricyclic antidepressants, chlorpromazine, ndi carbamazepine, zimatha kuyambitsa antidiuretic.Amachulukitsa chiwopsezo chosunga madzi.