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Manufacturer Supply Cilengitide 98% ufa woyera CAS NO.188968-51-6 Chithunzi Chowonetsedwa
  • Manufacturer Supply Cilengitide 98% ufa woyera CAS NO.188968-51-6
  • Manufacturer Supply Cilengitide 98% ufa woyera CAS NO.188968-51-6
  • Manufacturer Supply Cilengitide 98% ufa woyera CAS NO.188968-51-6

Manufacturer Supply Cilengitide 98% ufa woyera CAS NO.188968-51-6

Cilengitide CAS NO: 188968-51-6
Cilengitide ndi peptide ya cyclic pentapeptide yomwe imapikisana ndi arginine-glycine-aspartate (RGD) peptide sequence.Imawongolera kumanga kwa integrin-ligand.Cilengitide mosankha komanso mogwira mtima amaletsa alpha v beta 3 beta ndi alpha v 5 integrin kuphatikizapo matrix mapuloteni, monga Vitronectin, Fibronectin, Fibrinogen, vonWillebrandFactor, Osteopontin, ndi ena.10μMCingiChemicalbooktide imaletsa kwathunthu kumamatira kwa BAE, BME ndi ma HUVE ku Vitronectin ndi Fibronectin.Cilengitide imagwira ntchito mu vitro pama cell a BAE pretreated ndi FGF-2 (kapena VEGF-A) ya kolajeni yamitundu itatu ndi magazi a fibrin gel kuti aletse angiogenesis ndi IC50 ya 15 ndi 8μM, ndi 4 ndi 3μM, motsatana.Cilengitide imalepheretsa kuchuluka kwa ma cell, imapangitsa endothelial cell apoptosis, ndipo imapangitsa kusiyana kwa ma cell a endothelial precursor cell.


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Mafotokozedwe Akatundu

Dzina lazogulitsa Cilengitide
CAS 188968-51-6
mawonekedwe a molekyulu C27H40N8O7
kulemera kwa maselo 588.66
kachulukidwe 1.41±0.1 g/cm3(Zonenedweratu)
kusungunuka ≥29.43 mg/mL mu DMSO;≥22.56 mg/mL mu H2O
Acidity coefficient (pKa) 4.01±0.10 (Zonenedweratu)
kusintha (1)
kusintha (1)
konsati (2)

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